EndomeTRIO Test

Analyze your endometrium and improve your chances of pregnancy

Have you experienced implantation failure or recurrent miscarriages? The EndomeTRIO test is a comprehensive study of the endometrium that allows for personalized fertility treatment to improve the chances of success.

At Fertility Madrid, we offer this advanced analysis, which includes the ERA, EMMA, and ALICE tests.

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What is the EndomeTRIO test?

EndomeTRIO is a combination of three tests that analyze different aspects of endometrial health. Thanks to genomic sequencing (Next Generation Sequencing), we obtain key information to adjust the treatment and schedule the embryo transfer at the optimal time.

What tests are included in the EndomeTRIO test?

  • ERA (Endometrial Receptivity Analysis): analyzes endometrial receptivity to identify your personalized implantation window.
  • EMMA (Endometrial Microbiome Metagenomic Analysis): studies the endometrial microbiome and the presence of lactobacilli, which are associated with higher implantation rates.
  • ALICE (Analysis of Infectious Chronic Endometritis): detects the presence of bacteria that cause chronic endometritis and may hinder pregnancy.

Who is the EndomeTRIO test for?

The EndomeTRIO test is especially recommended for:

  • Women with implantation failure despite good-quality embryos
  • Women with recurrent miscarriages
  • Women diagnosed with or suspected of having chronic endometritis
  • Patients who want a comprehensive evaluation of their endometrial health before embryo transfer

Why is the endometrium so important?

A good-quality embryo is not enough to achieve pregnancy. The endometrium must be prepared to receive it, and that depends on factors such as receptivity, the endometrial flora, and the absence of infections.

Key facts about endometrial health

  • 30% of infertile women may have chronic endometritis
  • In cases of recurrent miscarriage or implantation failure, this percentage rises to 66%
  • The implantation window is displaced in 3 out of 10 women
  • A deficient or imbalanced endometrial microbiota can reduce success rates

How is the EndomeTRIO test performed?

The EndomeTRIO test is simple and is carried out in four steps:

Endometrial biopsy

A small sample of endometrial tissue is collected, usually during a specific phase of the menstrual cycle.

Genetic sequencing analysis (NGS)

Receptivity, the microbiome, and the possible presence of infections are studied.

Detailed report

Includes personalized medical recommendations.

Transferencia embrionaria optimizada:

Transferencia embrionaria optimizada: se programa en el momento más adecuado para maximizar las posibilidades de implantación. 

EndomeTRIO Test at Fertility Madrid

Book a free consultation
At Fertility Madrid, we offer the latest advances in assisted reproduction to help you achieve your dream of becoming a mother. Our medical team will assess whether the EndomeTRIO test is right for you and will support you throughout the entire process.
We are located in the center of Madrid:
C/ General Oraá, 47 – 28006 Madrid
Close to parking, metro lines, buses, and hotels.

Frequently asked questions about the EndomeTRIO test

What does the EndomeTRIO test cost?

The price of the test may vary depending on each case. Contact our medical team to receive a personalized quote.

Does the endometrial biopsy hurt?

The biopsy may cause discomfort similar to menstrual cramps, but it is a quick and outpatient procedure.

When is the test recommended?

It is generally performed in the cycle prior to embryo transfer, following specific instructions from the medical team.

How much does the EndomeTRIO test cost?

The price of the test may vary depending on each case. Contact our medical team to receive a personalized quote.

Does the endometrial biopsy hurt?

The biopsy may cause mild discomfort or cramping similar to menstruation. It is performed in a few minutes and does not require anesthesia.

When is the EndomeTRIO test recommended?

Mainly in women with recurrent implantation failure, repeated miscarriages, or when the goal is to personalize the optimal timing for embryo transfer.

What do the ERA, EMMA, and ALICE tests include?

  • ERA: Determines the personalized implantation window.

  • EMMA: Analyzes the endometrial microbiota.

  • ALICE: Detects the presence of pathogenic bacteria associated with chronic endometritis.

Can the test be done in any cycle?

No, it must be done in a specific cycle monitored by the doctor, so that the sample collection coincides with the endometrial phase that needs to be analyzed.

How long do the results of the EndomeTRIO test take?

Usually between 2 and 3 weeks, depending on the laboratory.

Does the EndomeTRIO test improve the success rate of IVF?

Yes, by allowing the embryo to be transferred at the most suitable time and treating possible infections or microbiota imbalances, it can increase the chances of pregnancy.